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The study involved 441 patients who received up to 4 injections of a phosphatidylcholine mixture

The nanosystem can release DOX by the low pH endosomes while up-taken by MDR/breast cancer cells and could silence the MDR1 gene and erythroblastosis virus E26 oncogene homolog 1 gene by MBs hybridizing with target sequences, plus it is capable of hindering DOX efflux transporter of P-glycoprotein expression and causing the progression of MDR breast cancer to desist

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Psychopharmacology 135:182193 Savasta M, Dubois A, Scatton B (1986) Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SCH 23390